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Neuerscheinungen: Chemie - 3/2011
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| Miguel Castanho, Nuno Santos (Hg.)
Peptide Drug Discovery and Development
Translational Research in Academia and Industry
Wiley, 2011, 370 S., Geb., EUR 139.00
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Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development.
Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.
Table of Content:
CHALLENGES AND STRATEGIES IN TRANSLATIONAL RESEARCH WITH PEPTIDE DRUGS Peptides as leads for drug discovery Marketing antimicrobial peptides: a critical academic point of view Oral peptide drug delivery: Strategies to overcome challenges Rational design of amphipathic alpha-helical and cyclic beta-sheet antimicrobial peptides: specificity and therapeutic potential Conotoxin-based leads in drug design Plant antimicrobial peptides: from basic structures to applied research PEPTIDE DRUGS BEFORE, THROUGH AND AFTER INDUSTRY PIPELINES Omiganan pentahydrochloride: a novel, broad-spectrum antimicrobial peptide for topical use Turning endogenous peptides into new analgesics: the example of kyotorphin derivatives The development of romiplostim—a therapeutic peptibody used to stimulate platelet production HIV vs. HIV: turning HIV-derived peptides into drugs Sifuvirtide, a novel HIV-1 fusion inhibitor WHITHER PEPTIDE DRUGS? -
PEPTIDES SHAPING THE FUTURE OF DRUG DEVELOPMENT Endogenous peptides and their receptors as drug discovery targets to treat metabolic disease Motilin and ghrelin receptor agonists as drugs for gastrointestinal disorders Of mice and men: Translational research on amylin agonism Peptides and polypeptides as immunomodulators and their consequential therapeutic effect in multiple sclerosis and other autoimmune diseases Development of antibody fragments for therapeutic applications
About the Author(s):
Miguel Castanho is head of the Biochemistry department of the School of Medicine at the University of Lisbon (Portugal). He also leads the Physical Biochemistry research unit at the Institute of Molecular Medicine. His main field of research is the interaction of peptide drugs with lipids, in particular the role of lipid membranes in the mechanism of action of peptide drugs.
Nuno C. Santos is the leader of the Biomembranes Unit of the Institute of Molecular Medicine. His research is centered on the specific functions of biological membranes lipids and proteins, with a special focus on their relevance for pathologic processes ranging from viral or bacterial infection to cardiovascular diseases.
Together, Miguel Castanho and Nuno C. Santos have been involved in many collaborative drug discovery and development projects with industry partners in Europe, USA, Canada, and China.
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